3 Health Benefits of Guggul + Side Effects

3 Health Benefits of Guggul + Side Effects

Guggul has long been used as a traditional medicine for a variety of health conditions. There is evidence that the active components inside this plant have antioxidant and anti-inflammatory activity. Learn about the potential health benefits of guggul as well as the side effects. Guggul is the most common name for a small medicinal tree Commiphora Mukul (Wightii), which is mostly found in the Indian subcontinent. In Ayurveda, guggul dry gum resin is obtained from the stem of the Guggul tree. It has been used for thousands of years in the Ayurvedic medicine system [ 1 ]. Guggul is one of the oldest Ayurvedic herbs taken orally for a variety of diseases. The term “guggul” in Sanskrit means “protects against diseases”. Guggul supplements are sometimes referred to as guggulipid or guggul lipid [ 2 ]. Despite its long history and purported health benefits, the available clinical research on guggul is limited. Guggul contains a mixture of sterols, steroids, esters, and alcohols with multiple purported benefits: Steroids and sterols : The main active component of guggul is thought to be guggulsterone (E and Z). Other steroids found in guggul include guggulsterone M, dihydroguggulsterone, and guggulsterol Y. These steroidal components may have anti-inflammatory properties [ 3 ] Triterpenoids : Myrrhanone (A, B) and Myrrhanol (A, B, C) may have anti-inflammatory activity [ 2, 4 ]. The following purported benefits of guggul are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of guggul for any of the uses listed below. Remember to speak with a doctor before taking guggul. It should never be used as a replacement for approved medical therapies. Lowering Cholesterol A number of older clinical trials performed in India show that guggul may help with high cholesterol. In these studies, supplementation with […]

How Do Memory Vitamins Work? (And the Best Brain Supplements)

How Do Memory Vitamins Work? (And the Best Brain Supplements)

There are a whole bunch of alleged memory vitamins and supplements to help you concentrate and boost your brain function. Unfortunately, there’s also a lot of misinformation, dodgy studies, and things we just don’t know when it comes to which vitamins actually help with memory and concentration. This article will dig into the current research to pick four of the best vitamins and supplements to boost your memory and overall brain function. Vitamin vs Supplement First, let’s talk about the difference between a vitamin and a supplement. Vitamins are simply organic compounds that are necessary in small quantities to sustain life. [1] We’re talking the vitamin A, B, Cs here. Vitamins are in the unprocessed, healthy foods you eat every day and are also available as daily supplements in pill form. Or as chewy, edible cartoon characters. Supplements are just extra pills, liquids, or cartoon characters that you consume in addition to the actual food you eat. Supplements can include but are not limited to vitamins, minerals, amino acids, herbs, hormone building blocks, and other compounds that are synthesized or extracted from natural sources. What Research Says About Vitamins and Supplements Now, we need to talk about the current state of the research on memory vitamins and brain supplements. The only real consensus seems to be that much more research needs to be done to truly answer which vitamins and supplements are best for your memory. Supplements are big business. In 2015, Americans spent 643 million dollars on supplements, and a quarter of Americans over 50 take them regularly. [2] That’s a lot of money spent on an extremely unregulated and under-researched industry. Here’s what we do know: The brain needs vitamins and minerals to function properly. We also have some studies on rats and in small samples of […]

Three Easy Things To Try With CBD Oil

Three Easy Things To Try With CBD Oil

The CBD market is forever growing, with new products basically pouring out of our phones, tablets, and laptops all the time. And, in a marketing strategy we simply go crazy for, companies are constantly pressed to think up newer, more bizarre, over the top applications. As a harmless consumer, how can we possibly think up our own fun, homemade CBD uses? To put it simply, CBD pickles probably exist, and it’s probably really beneficial to rub them on sore joints. The wonderful thing about CBD, though, is that you could probably somehow infuse it in pickles, and you probably could rub it on your tennis knee and feel relief (but, please, don’t hold me to that). There’s a reason CBD’s so popular, but this reason might also be the reason it may become commonplace sooner rather than later – its versatility. Because of CBD’s many applications, there’s a constant race in pretty much every industry for new and innovative products or uses. By exploring CBD’s versatility, let us show you why it’s so popular, and give you 3 new, easy ways to incorporate it into your day. So why has CBD become so, almost untouchably, popular? It turns out that the connection CBD and our bodies/brains is a match made in heaven. As you’re already probably fully aware, CBD is a natural compound called a phytocannabinoid found in hemp and cannabis plants. It won’t give you the same sense of ‘high’ or euphoria that THC will, although they are closely related. The ECS, Endocannabinoids, and Cannabinoids CBD works by interacting with our endocannabinoid systems, which are pretty amazing in their own right. There is still a lot to learn about this wonder-system, but what we do know is that the ECS helps regulate crucial functions throughout the body and […]

Burn Fat, Boost Testosterone, and Crush Your Fitness Goals with Modern Man

Burn Fat, Boost Testosterone, and Crush Your Fitness Goals with Modern Man

We all need a boost once in a while. If you’re having trouble dropping those last few pounds, maintaining a ripped physique, or just motivating to get off the couch and work out, try Modern Man v.3 Intense 2-in-1 Thermogenic and Testosterone Support . This is far more than your typical testosterone booster. Modern Man delivers fast-acting results you can see and feel, ultimately enhancing your flow state to keep you in the zone and reach your fitness goals. If you’re looking to get ripped, this is the stuff you need to take your fitness over the top. It transcends both testosterone boosters and fat burners. If you find yourself in an endless cycle of stress, fatigue, and irritability, rest assured you’re not alone. All guys go through this. How do some men stay positive, energized and focused? Modern Man can help. More Than Just A Testosterone Booster A constant state of stress can torpedo your natural testosterone production. With less testosterone, you’re more prone to store fat, have trouble building muscle, experience “brain fog,” and lose your drive. With muscle-preserving, fat-burning ingredients and natural testosterone support, bodybuilding experts and business professionals alike swear by Modern Man . It’s formulated with a very specific purpose: to help you reach your fitness goals. Getting in shape and achieving your goals adds confidence, which aids in natural testosterone production. So break the cycle of stress and fatigue. Get Modern Man . It’s more than just testosterone. By combining some of the top, most researched ingredients recommended by professional biohackers, Modern Man’s focus-enhancing complex provides a daily brain boost. Multiple nootropics work to boost cognitive function and increase your attention to detail. You will bust out of what’s known as “brain fog” and feel more alert and energetic in your mind. And […]

Your brain on sugar: What the science actually says

Your brain on sugar: What the science actually says

Summary: From reducing memory capability to increasing the risk of diabetes and obesity, researchers investigate how sugar affects the brain and body. Source: The Conversation We love sweet treats. But too much sugar in our diets can lead to weight gain and obesity, Type 2 diabetes and dental decay. We know we shouldn’t be eating candy, ice cream, cookies, cakes and drinking sugary sodas, but sometimes they are so hard to resist. It’s as if our brain is hardwired to want these foods. As a neuroscientist my research centres on how modern day “obesogenic,” or obesity-promoting, diets change the brain. I want to understand how what we eat alters our behaviour and whether brain changes can be mitigated by other lifestyle factors. Your body runs on sugar — glucose to be precise. Glucose comes from the Greek word glukos which means sweet. Glucose fuels the cells that make up our body — including brain cells (neurons). Dopamine “hits” from eating sugar On an evolutionary basis, our primitive ancestors were scavengers. Sugary foods are excellent sources of energy, so we have evolved to find sweet foods particularly pleasurable. Foods with unpleasant, bitter and sour tastes can be unripe, poisonous or rotting — causing sickness. So to maximize our survival as a species, we have an innate brain system that makes us like sweet foods since they’re a great source of energy to fuel our bodies. When we eat sweet foods the brain’s reward system — called the mesolimbic dopamine system — gets activated. Dopamine is a brain chemical released by neurons and can signal that an event was positive. When the reward system fires, it reinforces behaviours — making it more likely for us to carry out these actions again. Dopamine “hits” from eating sugar promote rapid learning to preferentially […]

Wake up refreshed: 7 tiny changes that’ll result in better sleep – every single night

Wake up refreshed: 7 tiny changes that'll result in better sleep – every single night

Sleep isn’t a luxury. In fact – skimping on zzz’s compromises everything from your immune system to your memory. When we sleep not only are we getting some much-needed rest from our increasingly busy lives, we are also allowing out body to pretty much regenerate and renew itself. It’s true. For instance, evidence suggests that the brain’s trillions of nerve cells literally rewire themselves when we sleep, and as for our skin – well, there is a reason it is called beauty sleep, you know. Getting enough sleep is all sorts of good for our health, and can actually reduce your risk for heart problems, obesity, high blood pressure, diabetes and even cancer. The general advice is that we should aim for between seven and nine hours of sleep at night, something many of us struggle to get. However, sometimes small changes can end up having big and long-lasting effects , and if you are struggling with your sleep, try making one (or all) of these adjustments and see how you get on: 1. Ditch the afternoon latte If you have trouble falling asleep at night or if your sleep is restless , caffeine may be the issue. Our ability to recover from the effect of caffeine diminishes as we age, so it may be time to give up late-night coffees—or even late-afternoon ones. 2. Swap your regular cuppa for camomile tea Experts are out on whether or not herbal teas actually have an effect of sleep, but what we do know is that a calming evening routine can massively improve your chance of falling asleep when you head hits the pillow. Entering sleep in a more relaxed state aids in the quality of sleep you get. Even if tea isn’t a cure-all in terms of sleep, it’s also […]

10 Acetylcholine Benefits, Function & Supplements

10 Acetylcholine Benefits, Function & Supplements

Acetylcholine is a hot topic within the realm of memory enhancement. It is a neurotransmitter that is critical for the everyday functioning of the brain, particularly in the areas of movement, learning & memory, and sleep quality. Check out this post to learn how to promote balanced acetylcholine in your body and function at your very best. What Is Acetylcholine? Acetylcholine is used by organisms in all domains of life for a variety of purposes. It is believed that choline , a precursor to acetylcholine, was used by single-celled organisms billions of years ago, for creating the cell layers [ 1 ]. Acetylcholine is a neurotransmitter that is used for many things: from stimulating muscles to memory and sleep . Acetylcholine is synthesized from acetyl-CoA (which comes from glucose) and choline, with the help of the enzyme choline acetyltransferase [ 2 ]. Acetylcholine controls movements by causing muscle contractions. Acetylcholine and histamine interact together to contract muscles in the lungs [ 3 , 4 ]. In the brain, it is involved in memory and attention, and promotes the phase of sleep associated with dreaming (REM sleep) [ 5 , 6 , 7 ]. Too little acetylcholine in the memory center of the brain (hippocampus) has been associated with dementia and Alzheimer’s [ 5 ]. Scopolamine, a drug that blocks acetylcholine, impaired acquisition of new information in humans and animals [ 8 , 9 ]. In monkeys, disruption of the supply of acetylcholine to the brain (neocortex, hippocampus) impaired the acquisition of factual information (discrimination learning) and also produced forgetting comparable to human amnesia [ 10 , 11 ]. In an observational study on almost 1400 people, higher choline intake was related to better cognitive performance (verbal and visual memory) [ 12 ]. There is a link between acetylcholine and […]

12 Health Benefits of Saffron + Side Effects & Dosage

12 Health Benefits of Saffron + Side Effects & Dosage

Saffron, often referred to as the ”golden spice” has been used as a seasoning and coloring agent in food for centuries. Modern research confirms the benefits of saffron for mental health, eyesight, and immunity, but casts doubt on other traditional uses. Read on to discover the uses, benefits, and side effects of saffron. Saffron, also known as Za’faran, is a spice derived from the Crocus sativus plant. Alluding to its yellow color and high cost, saffron is often referred to as the Golden Spice. Saffron has been used as a seasoning in food and as a coloring agent for over 4 millennia. Today, over 90% of the world’s saffron supply stems from Iran [ 1 ]. The Crocus sativus flower consists of thread-like, crimson-colored structures known as stigmas. The stigmas are collected and dried, resulting in the saffron spice [ 1 ]. Saffron is composed of a variety of chemical compounds that give rise to its taste, color and health benefits. Proponents: May help with Alzheimer’s disease May relieve depression Helps with painful periods and PMS Supports the immune system May enhance physical performance May protect the brain, heart, and liver Most benefits lack stronger clinical evidence Effective doses can’t be reached without supplements Cooking may destroy some beneficial components Potentially dangerous to pregnant women Historically, saffron was used in traditional medicine to treat a variety of ailments including: Similarly, saffron was often included in various preparations used for pain relief [ 1 ]. In modern medicine, saffron has gained popularity for its wide range of therapeutic applications, including but not limited to [ 1 , 2 ]: Today, a number of saffron formulations exist containing doses that have been proven to have a positive outcome. These include [ 3 ]: Itch cream Scar removal cream Tablets Infusion into […]

17 Histamine Health Effects: Cognition, Inflammation & Sleep

17 Histamine Health Effects: Cognition, Inflammation & Sleep

Histamine is often cast as a villain for its role in inflammation and allergies, but this neurotransmitter regulates sleep, appetite, sexual behavior, and more. Read on to learn about the many vital functions of this inflammatory signal molecule. You may have landed here from our previous post on histamine. If so, you know that this biogenic amine acts on four receptors (H1R, H2R , H3R , and H4R ) to regulate sleep, appetite, motivation , learning, memory, and sexual behavior. If not, you may want to read that post before continuing into this deep dive into the health effects of histamine. Health Effects of Histamine You may have heard some pretty bad things about histamine. It tends to be discussed in the context of bug bites, itching, and allergies, but histamine is extremely important to your body’s daily function. 1) Alertness and Wakefulness Histamine sets your circadian clock . The first type of histamine receptor, H1R, helps you stay awake . Many antihistamine medications block this receptor, which is why they can make you drowsy [ 1 , 2 , 3 ]. H3R, by contrast, lowers histamine and promotes sleep . Neurons that release histamine are active during the day, stop working as you get drowsy in the evening, and start again after you wake up [ 4 ]. Low brain histamine can make you excessively sleepy during the day . It might also make waking up in the morning a struggle , even if you got enough sleep . People with narcolepsy have low brain histamine and uncontrollably fall asleep during the daytime. Tiprolisant is a drug that can increase their wakefulness and brain histamine by blocking H3R [ 3 , 5 ]. Histamine helps you stay awake during the day, which is why antihistamine medications can make […]

Pregnenolone Uses, Side Effects & Safety

Pregnenolone Uses, Side Effects & Safety

Pregnenolone is a hormone that the body produces from cholesterol. Despite a lack of effectiveness and safety data, pregnenolone made its way into some compounding pharmacies and bodybuilding products. However, many users are not told that pregnenolone is not a dietary supplement but an unapproved drug. What is Pregnenolone? Pregnenolone is a steroid hormone that the adrenal glands, brain, and gonads produce from cholesterol. In the body, it’s considered a precursor of other steroid hormones like testosterone, progesterone, cortisol, and estrogen. That’s why it’s sometimes referred to as a “prohormone” [ 1 , 2 , 3 , 4 ]. There’s been some research on pregnenolone in the past decades, mostly in lab animals. Proper scientific evidence is lacking to determine the effectiveness and safety of pregnenolone. Despite this, some companies advertise pregnenolone as an anti-aging and nootropic compound. It has been marketed for boosting the production of other hormones. Some claim it may make people feel more energetic and youthful. These claims are unsubstantiated. The FDA issued a warning letter to New York-based company called American Hormones for illegally producing pregnenolone [ 5 ]. This is a serious violation. In the letter, the FDA states that pregnenolone is a new unapproved drug since it is not generally recognized as safe and effective for the labeled uses among experts. What’s more, the company in question purported to be a compounding pharmacy, although they were actually operating as a pharmaceutical manufacturer. This poses a major risk to public health . Manufacturers that don’t follow laws and regulations sell potentially dangerous, adulterated, and misbranded compounds to consumers. The same company also made numerous unsubstantiated claims about “bioidentical hormones” such as progesterone . Pregnenolone is not explicitly listed on the World Anti-Doping Agency (WADA) Prohibited List. However, all non-approved substances are on the […]