Brighteon Broadcast News, Dec 10, 2024 New study proves that jabbed humans are WALKING BIOWEAPONS that shed toxins to others nearby 12/10/2024 // Laura Harris // 360 Views

Tags: autism , Autism spectrum disorder , badhealth , badpollution , badscience , brain damaged , brain health , breakthrough , children’s health , discoveries , Ecology , environment , health science , Mind , mind body science , neurological , real investigations , research , toxic chemicals , toxins Parents with high chemical intolerance are significantly more likely to have children diagnosed with autism (nearly six times) and ADHD (more than twice).

The study found higher odds ratios compared to a 2015 study, with mothers with chemical intolerance having 5.29 and 3.18 times the odds of having a child with autism and ADHD, respectively.

Environmental toxicants, including fossil fuel derivatives, pesticides and biogenic toxicants, can trigger chemical intolerance, leading to immune system dysregulation and potential genetic effects across generations.

Experts emphasize the importance of epigenetics in understanding diseases like autism, highlighting the impact of environmental factors on gene expression.

The study challenges the view that autism is purely genetic, instead pointing to environmental toxins, immune system dysregulation and epigenetic factors as key contributors to the disorder.

A new study published in the Journal of Xenobiotics has revealed that parents with high chemical intolerance are nearly six times more likely to have children diagnosed with autism and more than twice as likely to have children diagnosed with attention deficit hyperactivity disorder (ADHD).

The study, which replicates findings from a similar study in 2015, shows higher odds ratios than before. Mothers with chemical intolerance now have 5.29 and 3.18 times the odds of having a child with autism (up from 3.01) and ADHD (up from 2.3), respectively. The increase likely stems from heightened environmental toxin exposure, expanding diagnostic criteria and cumulative chemical burdens. The study also revealed a high autism prevalence of 12.3 percent among participants, much higher than the reported 1 in 36 by the Centers for Disease Control and Prevention .

According to research scientist and author James Lyons-Weiler, Ph.D., this rise is attributed to factors such as immune system dysregulation caused by chemical exposures and adjuvants like aluminum in vaccines.

“A combination of increased environmental toxicant exposures, expanding diagnostic criteria and increased exposure to myriad corporate toxins that induce cell death via ER stress [endoplasmic reticulum stress] and the unfolded protein response. The contribution of an expanded vaccination schedule, particularly involving adjuvants like aluminum, is known to be an environmental cause of ER stress and cell death and thus has neurotoxic, neurodevelopmental and immunomodulatory effects,” Lyons-Weiler said.

The study also identified mast cells — immune cells in connective tissue — as a potential agent for chemical intolerance. This intolerance could be triggered by fossil fuel derivatives, pesticides, antibiotics and biogenic toxicants like toxic mold and algae.

Mast cells can undergo gene activation or deactivation, with effects transmitted across generations. This process, called Toxicant-Induced Loss of Tolerance, involves initial exposure to toxicants followed by triggering symptoms after subsequent exposures.

“The study’s authors appropriately highlight environmental toxicants as key contributors but avoid injected toxicants like mercury and aluminum in their discussion, despite the past studies in which these compounds are also shown to cause ER stress and cell death. They could have further emphasized the role of cumulative and synergistic effects among the various classes of factors: the more toxicants kids are exposed to, the fewer vaccines they can handle and vice versa,” Lyons-Weiler said.

Moreover, the study links the increase in autism cases to “toxic exposure theory.” Dr. Karl Jablonowski, a senior research scientist at Children’s Health Defense , described the “dramatically increased exposure to toxins” such as pesticides, plastics, vaccines, pharmaceuticals and off-gassing materials as key contributors. Jablonowski also stressed epigenetics, the study of how environmental factors influence gene expression, as a major paradigm shift in understanding diseases like autism.

Lyons-Weiler warned that as toxicants in the environment increase , genetic predisposition may become less relevant, with all individuals potentially vulnerable. “Though we have our instructions for life in our DNA, how those instructions are used depends on epigenetics. Given the toxic soup we live in, the idea that a toxic exposure event in one generation can affect the genetic expression of future generations is scary.” Experts: Autism is not a purely genetic disorder

Autism experts claim that the study has challenged the long-standing view that autism is purely a genetic disorder.

Biologist Dr. Christina Parks pointed to the focus of the study on immune system dysregulation. She described it as a critical factor in disorders previously considered purely psychological or neurological. “Every day, our bodies have to decide whether to ignore particles we come into contact with or to attack these particles. Repeated chemical exposure can throw the immune system into a frenzy, such that it starts attacking things that it previously tolerated,” she said. (Related: NEW STUDY: Autism is not just a neurological condition but a whole system disorder driven by environmental toxins .)

John Gilmore, executive director of the Autism Action Network, echoed this perspective. He stated that autism occurs in genetically vulnerable individuals who are exposed to environmental factors. “We know there is no such thing as a genetic epidemic, which has been the overwhelmingly dominant area of autism causation research. We also know that people with autism are much more likely to come from families with histories of auto-immune disorders.”

In line with this, Lyons-Weiler noted that both genetics and environmental toxicants contribute to autism risk, with evidence stressing chemical intolerance’s role in neurodevelopmental issues.

Read more stories about autism at AutismTruthNews.com .

Watch the video below to learn more about the 2nd Brighteon Autism Conference Spring 2023: End The Autism Epidemic .

This video is from the BrighteonTV channel on Brighteon.com . More related stories:

These SEVEN studies point to the inescapable conclusion: VACCINES DO CAUSE AUTISM and other chronic health conditions .

Over 300 pages of evidence from the CDC show that vaccines cause autism .

Study: Early exposure to smartphones, online content linked to increased […]

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Working out can help improve your memory for up to 24 hours, a new study says. (Getty Images) Decades of research has found that exercise is helpful for overall health and fitness, doing everything from lowering your risk of heart disease to helping you sleep better. According to a new study, working out could also help boost your memory — and the results may stick around for up to a day after your sweat session.

The small study , published today in the International Journal of Behavioral Nutrition and Physical Activity, analyzed data from 76 people aged 50 to 83 who wore activity trackers for eight days and took cognitive tests daily. The researchers discovered that people who did more moderate to vigorous physical activity than usual on any given day ended up performing better in memory tests the next day.

Being active in general also seemed to help. People who spent less time than usual sitting and logged six hours more of sleep also had better scores on memory tests.

The findings could have big implications for everyone, including older adults “where it’s very important to understand factors that could maintain daily cognitive function,” Mikaela Bloomberg , lead study author and senior research fellow at University College London, tells Yahoo Life.

But what’s behind this link, and how much exercise do you need to do to get the benefits? Doctors explain. Why might exercise boost your brain?

It’s important to point out that this isn’t the first study to link exercise with better memory. Previous research has found that people performed better on memory tests in the hours after they exercised, but many studies haven’t pinned down how long those perks last.

Doctors say there are a few different things that could be behind the memory boost from exercise. “Exercise leads to increased blood flow and stimulation of neurotransmitters thought to contribute to improvements in cognitive function,” Bloomberg says. ( Neurotransmitters help to move messages from one nerve cell to the next and help with memory and thinking.)

Exercise can also prompt the birth of new neurons in the hippocampus, which is an area of the brain that’s essential for memory and learning, Dr. Vernon Williams , sports neurologist and founding director of the Center for Sports Neurology and Pain Medicine at Cedars-Sinai Kerlan-Jobe Institute in Los Angeles, tells Yahoo Life. “Exercise also promotes neuroplasticity, the brain’s ability to form new connections and reorganize itself,” he says.

Exercise can even help lower inflammation in the brain, which is linked to cognitive decline, Williams says. How much exercise do you need to do?

The researchers didn’t find a hard number for how much exercise is needed to get the brain benefits. “We just looked at when people did more physical activity than their usual,” Bloomberg says. “Regardless of their current level of physical activity, doing more was better.” So if you regularly work out for 30 minutes, tacking on an additional five minutes of exercise may help you feel mentally sharp over the next 24 hours.

In the study, doing more moderate or vigorous physical activity than usual was linked to better working memory and memory of events the next day. Also worth noting: Spending time being more sedentary than usual was linked to worse working memory the next day. Why it matters

Bloomberg stresses that her study was small, which makes it difficult to take too much away from the findings without more research. But she also says that there could be real-world ways to use the results to your advantage.

For older adults, having a workout routine may help to boost memory and keep people sharp as they age. And if you have an upcoming test or big presentation, making sure to exercise at some point the day before “couldn’t hurt” when it comes to enhancing your memory, Bloomberg says.

While this particular study found that working out more than usual had an impact, Williams says it’s important to have a consistent exercise routine for brain health and memory too. “There is also likely some cognitive stimulation associated with regular physical activity that may also play a beneficial role,” he says. What’s the best form of exercise for memory?

This study found that you don’t need to do anything extreme to get a memory boost from exercise. Bloomberg says that exercises that fall into the “moderate intensity” or higher category, such as brisk walking, cycling or jogging, helped to boost memory.

However, other research has found more intense exercises can also help. A study recently published in the journal Communications Psychology , for example, determined that cycling and high-intensity interval training (HIIT) were most likely to help boost memory, attention, executive function, information processing and other cognitive functions.

Overall, Bloomberg says research makes a case for staying active as you get older. “There are many health reasons why older adults should integrate physical activity into their daily lives, and there is certainly evidence to suggest that doing so might contribute to maintenance of cognitive function as we age,” she says.

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Tags: alternative medicine , Alzheimer’s disease , brain function , brain health , cognitive function , cognitive health , dementia , goodhealth , goodmedicine , goodscience , health science , herbal medicine , Herbs , Huntington’s disease , natural cures , natural health , natural medicine , Parkinson’s Disease , phytonutrients , rue In the search for solutions to tackle neurodegenerative diseases like Alzheimer’s disease, Huntington’s disease and Parkinson’s disease, scientists are exploring the natural world for inspiration. One plant making waves in this field is Ruta graveolens or rue – a hardy, shrubby herb native to the Mediterranean. Long celebrated in traditional medicine for its diverse medicinal properties, rue is now being investigated for its potential to promote and restore brain health and function.

Rue has a rich history in traditional and folk medicine where it has been used to treat ailments ranging from aching pain and skin conditions to neurological disorders like multiple sclerosis.

Researchers are focusing on rue’s impact on the central nervous system (CNS), aiming to uncover how its chemical compounds could support brain health and combat the mechanisms behind debilitating diseases.

Rue owes much of its potential to a powerful metabolite called “rutin.” Discovered in 1936 and sometimes referred to as vitamin P, rutin is a flavonoid known for its antioxidant and anti-inflammatory properties. These attributes make rutin a promising candidate for addressing the oxidative stress and inflammation linked to neurodegenerative diseases. Additionally, rutin has been found to inhibit harmful enzymes, protect neurons from toxins and promote cell survival. Alzheimer’s disease

Alzheimer’s disease is characterized by memory loss and cognitive decline, caused in part by the death of cholinergic neurons and the buildup of harmful beta-amyloid plaques. Rue and rutin show promise in counteracting these effects. (Related: Coconut oil improves brain function in Alzheimer’s patients .)

Boosts acetylcholine levels. Rue acts as an acetylcholinesterase (AChE) inhibitor, helping maintain levels of acetylcholine – a neurotransmitter vital for learning and memory. This mechanism is similar to that of drugs like donepezil, but without the gastrointestinal side effects often seen with these medications.

Fights plaques and inflammation. Studies show that rutin reduces beta-amyloid plaques in animal models, while decreasing inflammation markers like pro-inflammatory cytokines. This dual action could slow disease progression and improve neuronal survival.

Improves memory. Animal studies suggest that rutin enhances learning and memory – likely through its anti-inflammatory and antioxidant effects. It may also activate microglial cells (immune cells in the brain) to clear harmful proteins. Parkinson’s disease

In Parkinson’s disease, the gradual loss of dopamine-producing neurons leads to motor symptoms, such as tremors and rigidity. Rue and its metabolite rutin have demonstrated promising effects in preclinical studies.

Inhibits harmful enzymes. One major contributor to Parkinson’s is monoamine oxidase B (MAO-B) – an enzyme that breaks down dopamine. Rue’s ability to inhibit MAO-B helps preserve dopamine levels – similar to existing Parkinson’s treatments like selegiline. But rue’s benefits do not stop there – rutin also reduces oxidative stress and prevents the formation of harmful byproducts that damage neurons.

Protects dopaminergic neurons. In animal studies, oral rutin administration protected brain cells from toxins that mimic Parkinson’s symptoms. Notably, treated animals showed improved movement and brain health – suggesting rutin might slow disease progression.

Enhances neural plasticity. Rue extracts promote neurite outgrowth – a process crucial for repairing and forming connections between neurons. This suggests a role in enhancing the brain’s adaptability and resilience . Huntington’s disease

Huntington’s disease is a genetic disorder that causes movement problems and cognitive decline. Research into rue’s impact in Huntington’s, while less extensive, has yielded intriguing findings.

Counteracts toxins. In animal models, rutin protected neurons from toxic substances that mimic Huntington’s disease symptoms – improving cell survival and reducing damage.

Supports cellular health. A study using the model organism C. elegans found that rutin delayed aging, reduced neuronal cell death and activated pathways involved in cellular repair. These findings point to rutin’s potential for promoting brain health. Neural plasticity and cell survival

One of the most exciting aspects of rue is its ability to influence signaling pathways that govern neural plasticity – the brain’s ability to adapt and form new connections. Rue extracts have been shown to:

Activates growth pathways. By stimulating signaling molecules like Akt and ERK, rue promotes cell survival and differentiation. These pathways are essential for repairing damage in conditions like Alzheimer’s, Parkinson’s and Huntington’s.

Promotes differentiation of neural cells. Rue extract encourages undifferentiated neural cells to develop into specialized neurons – a critical step in brain repair.

As researchers uncover more about its role in promoting neural health, rue may one day become a valued ally in the fight against brain diseases .

Watch this video about the herbal medicine benefits, uses and side effects of rue . This video is from the Holistic Herbalist channel on Brighteon.com . More related stories:

Studies show these three herbal medicines can reverse DEMENTIA .

Studies suggest these nutrients can help lower your dementia risk .

Here’s how fermented foods can support brain health .

Sources include:

PMC.NCBI.NLM.NIH.gov

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Regenerating neurons may be one way to improve cognition. Your brain can still make new neurons when you’re an adult. But how does the rare birth of these new neurons contribute to cognitive function?

Neurons are the cells that govern brain function , and you are born with most of the neurons you will ever have during your lifetime. While the brain undergoes most of its development during early life, specific regions of the brain continue to generate new neurons throughout adulthood, although at a much lower rate . Whether this process of neurogenesis actually happens in adults and what function it serves in the brain is still a subject of debate among scientists.

Past research has shown that people with epilepsy or Alzheimer’s disease and other dementias develop fewer neurons as adults than people without these conditions. However, whether the absence of new neurons contributes to the cognitive challenges patients with these neurological disorders face is unknown.

We are part of a team of stem cell researchers , neuroscientists , neurologists, neurosurgeons and neuropsychologists. Our newly published research reveals that the new neurons that form in adults’ brains are linked to how you learn from listening to other people .

Related: Trigger for deadly neurodegenerative disorder identified New neurons and learning

Researchers know that new neurons contribute to memory and learning in mice . But in humans, the technical challenges of identifying and analyzing new neurons in adult brains, combined with their rarity, had led scientists to doubt their significance to brain function.

To uncover the relationship between neurogenesis in adults and cognitive function, we studied patients with drug-resistant epilepsy . These patients underwent cognitive assessments prior to and donated brain tissue during surgical procedures to treat their seizures. To see whether how many new neurons a patient had was associated with specific cognitive functions, we looked under the microscope for markers of neurogenesis. Sign up for the Live Science daily newsletter now

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Contact me with news and offers from other Future brandsReceive email from us on behalf of our trusted partners or sponsorsBy submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over. Newborn neurons (green and purple) in brain tissue from human epilepsy patients. We found that new neurons in the adult brain are linked to reduced cognitive decline — particularly in verbal learning , or learning by listening to others.

This was very surprising to us. In mice, new neurons are known for their role in helping them learn and navigate new spaces through visual exploration . However, we did not observe a similar connection between new neurons and spatial learning in people. Improving cognition

Talking with others and remembering those conversations is an integral part of day-to-day life for many people. However, this crucial cognitive function declines with age , and the effects are more severe with neurological disorders . As aging populations grow , the burden of cognitive decline on health care systems worldwide will increase.

Our research suggests that the link between newborn neurons and verbal learning may be foundational to developing treatments to restore cognition in people. Enhancing new neuron generation could be a potential strategy to improve brain health and restore cognition in aging and in people with epilepsy or dementia. But for now, these ideas are just goals and any future treatments are a long way off.

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Importantly, our finding that new neurons function differently in mice and in humans emphasizes the critical need to study biological functions like neurogenesis in people whenever possible. This will ensure that research conducted in animal models, such as mice, is relevant to people and can translate to the clinic.

Current drugs for epilepsy primarily aim to reduce seizures, with limited focus on addressing the cognitive decline patients experience. To enhance cognitive outcomes for patients, we started a clinical trial focusing on boosting new neuron production and cognition in epilepsy patients through aerobic exercise. We are currently in the early Phase 1 of the clinical trial, which seeks to establish the safety of the study. Thus far, two patients have successfully and safely finished the study. We plan to recruit eight more patients to exercise and complete this phase.

By bringing together basic science in the lab and clinical research in people, a better understanding of brain regeneration could help support brain health throughout the lifespan.

This edited article is republished from The Conversation under a Creative Commons license. Read the original article .

Postdoctoral Research Associate in Stem Cell Biology and Regenerative Medicine, University of Southern California

Aswathy Ammothumkandy is a postdoctoral research associate at the University of Southern California’s Stem Cell department with 15 years of experience in neuroscience, epilepsy, cancer biology and stem cell research. She collaborates with neurologists, neurosurgeons and neuropsychologists to study neuronal hyperactivity and cognitive decline in epilepsy patients using surgically resected brain tissue. Her goal is to bridge basic and clinical sciences to uncover new biomarkers and therapies for neurological diseases.

Read more at www.livescience.com

New research indicates that generating new brain cells in adults supports verbal learning and memory, linking reduced neurogenesis with cognitive decline and highlighting potential therapeutic approaches to enhance cognitive health. Credit: SciTechDaily.com Researchers at USC have discovered that the formation of new brain cells in adults, known as neurogenesis, is essential for verbal learning and memory.

This study, utilizing brain tissues from epilepsy patients, shows a direct correlation between decreased neurogenesis and cognitive decline, opening the door to therapies that could enhance cognitive function by promoting neurogenesis. Adult Neurogenesis and Cognitive Function

Why do adults grow new brain cells? A groundbreaking study published today (December 5) in Cell Stem Cell offers the first direct evidence that the generation of new brain cells in adulthood supports verbal learning and memory. This ability helps people engage in conversations and retain what they hear. The findings may pave the way for innovative treatments to restore cognitive function.

The research, conducted by scientists at USC Stem Cell and the USC Neurorestoration Center at the Keck School of Medicine, examined brain tissue from patients with drug-resistant mesial temporal lobe epilepsy (MTLE). This condition is characterized by seizures and accelerated cognitive decline. Newborn neuron (green and purple cell) in brain tissue from patients with epilepsy. Credit: Aswathy Ammothumkandy/Bonaguidi Lab/USC Stem Cell Exploring the Link Between Neurogenesis and Verbal Learning

“Treating patients with epilepsy allows us to investigate the purpose of generating new neurons in our brains. We observe that one of reasons is to learn from the conversations we have” said co-corresponding author Michael Bonaguidi, an associate professor of stem cell biology and regenerative medicine, gerontology, biochemistry and molecular medicine, biomedical engineering, and neurological surgery, and assistant director of the USC Neurorestoration Center.

“These findings are clearly important for all people who suffer from learning and cognitive decline, but they are also specifically relevant to the epilepsy patients who participated in the research,” added co-corresponding author Charles Liu, a professor of neurological surgery, neurology, and biomedical engineering, director of the USC Neurorestoration Center, and director of the USC Epilepsy Care Consortium. Research Methodology and Findings in Epilepsy Patients

In the study, first authors Aswathy Ammothumkandy and Luis Corona from USC and their collaborators investigated how the process of making new brain cells—called neurogenesis—affects different types of cognitive decline during the progression of MTLE.

The researchers found that MTLE patients experience cognitive decline in many areas including verbal learning and memory, intelligence, and visuospatial skills. For verbal learning and memory, as well as for intelligence, patients undergo a dramatic decline during the first 20 years of seizures. During those same two decades, neurogenesis slows to the point where immature brain cells became nearly undetectable. Implications of Neurogenesis on Cognitive Health

Based on these observations, the scientists searched for links between the number of immature brain cells and the major areas of MTLE-related cognitive decline. They found the strongest association occurs between the declining number of immature brain cells and verbal learning and memory.

This is a surprising finding because neurogenesis levels in rodents and other lab animals contribute to a different type of learning and memory using visuospatial skills. The role of neurogenesis in verbal learning and memory highlights the value of studying human brain tissue. These highly valuable surgical specimens were generously donated by patients of the Rancho Los Amigos Epilepsy Center- a unique resource in the public safety-net health system advancing health care and research equity for the underinsured population in the region. During the complex operations, the neurosurgeons carefully removed the affected hippocampus in one piece, curing the majority of the patients of their seizures.

“Our study provides the first cellular evidence of how neurogenesis contributes to human cognition—in this case, verbal learning and memory,” said Bonaguidi. “This work opens a gateway for future studies exploring ways to improve verbal learning and memory by boosting neurogenesis, possibly through exercise or therapeutic drugs. Those approaches could help not only patients with MTLE, Alzheimer’s disease and dementia, but also all of us with aging brains.”

Reference: “Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progression” 5 December 2024, Cell Stem Cell .
DOI: 10.1016/j.stem.2024.11.002

Neuropsychologist Jason Smith from the Medical University of South Carolina is also a co-corresponding author. Additional authors are: Kristine Ravina, Victoria Wolseley, Jeremy Nelson, Nadiya Atai, Aidin Abedi, Lina D’Orazio, Alisha Cayce, Carol McClearly, George Nune, Laura Kalayjian, Darrin Lee, Brian Lee, Christianne Heck, Robert Chow, and Jonathan Russin from USC; Nora Jimenez from Los Angeles General Medical Center; Michelle Armacost from USC and Rancho Los Amigos National Rehabilitation Center; and Virginia Zuverza-Chavarria from Rancho Los Amigos National Rehabilitation Center.

Thirty percent of this work was supported by federal funding from the National Institutes of Health (grants R56AG064077, R01AG076956, and U01MH098937). Additional support came from the Donald E. and Delia B.Baxter Foundation, L.K. Whittier Foundation, Simon-Strauss Foundation, Cure Alzheimer’s Fund, Eli and Edythe Broad Foundation, USC Neurorestoration Center, Rudi Schulte Research Institute, American Epilepsy Society, and California Institute for Regenerative Medicine.

Read more at scitechdaily.com

Regenerating neurons may be one way to improve cognition. stanislavgusev/RooM via Getty Images Your brain can still make new neurons when you’re an adult. But how does the rare birth of these new neurons contribute to cognitive function?

Neurons are the cells that govern brain function , and you are born with most of the neurons you will ever have during your lifetime. While the brain undergoes most of its development during early life, specific regions of the brain continue to generate new neurons throughout adulthood, although at a much lower rate . Whether this process of neurogenesis actually happens in adults and what function it serves in the brain is still a subject of debate among scientists.

Past research has shown that people with epilepsy or Alzheimer’s disease and other dementias develop fewer neurons as adults than people without these conditions. However, whether the absence of new neurons contributes to the cognitive challenges patients with these neurological disorders face is unknown.

We are part of a team of stem cell researchers , neuroscientists , neurologists, neurosurgeons and neuropsychologists. Our newly published research reveals that the new neurons that form in adults’ brains are linked to how you learn from listening to other people . New neurons and learning

Researchers know that new neurons contribute to memory and learning in mice . But in humans, the technical challenges of identifying and analyzing new neurons in adult brains, combined with their rarity, had led scientists to doubt their significance to brain function.

To uncover the relationship between neurogenesis in adults and cognitive function, we studied patients with drug-resistant epilepsy . These patients underwent cognitive assessments prior to and donated brain tissue during surgical procedures to treat their seizures. To see whether how many new neurons a patient had was associated with specific cognitive functions, we looked under the microscope for markers of neurogenesis. Newborn neuron (green and purple) in brain tissue from human epilepsy patients. We found that new neurons in the adult brain are linked to reduced cognitive decline – particularly in verbal learning , or learning by listening to others.

This was very surprising to us. In mice, new neurons are known for their role in helping them learn and navigate new spaces through visual exploration . However, we did not observe a similar connection between new neurons and spatial learning in people. Improving cognition

Talking with others and remembering those conversations is an integral part of day-to-day life for many people. However, this crucial cognitive function declines with age , and the effects are more severe with neurological disorders . As aging populations grow , the burden of cognitive decline on health care systems worldwide will increase.

Our research suggests that the link between newborn neurons and verbal learning may be foundational to developing treatments to restore cognition in people. Enhancing new neuron generation could be a potential strategy to improve brain health and restore cognition in aging and in people with epilepsy or dementia. But for now, these ideas are just goals and any future treatments are a long way off.

Importantly, our finding that new neurons function differently in mice and in humans emphasizes the critical need to study biological functions like neurogenesis in people whenever possible. This will ensure that research conducted in animal models, such as mice, is relevant to people and can translate to the clinic.

Current drugs for epilepsy primarily aim to reduce seizures, with limited focus on addressing the cognitive decline patients experience. To enhance cognitive outcomes for patients, we started a clinical trial focusing on boosting new neuron production and cognition in epilepsy patients through aerobic exercise. We are currently in the early Phase 1 of the clinical trial, which seeks to establish the safety of the study. Thus far, two patients have successfully and safely finished the study. We plan to recruit eight more patients to exercise and complete this phase.

By bringing together basic science in the lab and clinical research in people, a better understanding of brain regeneration could help support brain health throughout the lifespan.

Read more at theconversation.com

In the realm of traditional Indian herbs, Shankhpushpi (Convolvulus pluricaulis) has long been revered for its cognitive and calming properties. Known as a “brain tonic,” Shankhpushpi is a key herb in Ayurveda, often used to enhance memory, reduce stress, and improve cognitive function. Now available in various forms, Shankhpushpi tea has gained popularity for its soothing effects and multiple health benefits, which modern research is starting to support. 1. Cognitive Enhancement and Memory Support

One of the primary reasons Shankhpushpi tea is so valued is for its role in supporting brain health. Traditionally, it has been used as a natural nootropic—a substance that enhances cognitive function without causing adverse side effects. Research published in the Indian Journal of Psychiatry highlights Shankhpushpi’s potential for enhancing learning, memory retention, and recall ability. The study found that the herb contains alkaloids and flavonoids that can modulate neurotransmitters, which play a crucial role in cognitive function and memory formation. Regular consumption of Shankhpushpi tea is said to boost cognitive clarity and may help in mitigating age-related cognitive decline. 2. Reduces Anxiety and Stress

Modern lifestyles often expose individuals to chronic stress and anxiety, which can take a toll on overall well-being. Shankhpushpi tea has traditionally been used as an adaptogen, helping the body manage and adapt to stress. A study published in the Journal of Herbal Medicine found that Shankhpushpi has a calming effect due to the presence of glycosides and flavonoids that act on the brain’s GABA receptors, the neurotransmitters responsible for relaxation. By balancing stress hormones like cortisol, Shankhpushpi tea can support a more balanced mood, helping reduce anxiety symptoms naturally. Consuming this tea daily could be an effective, natural way to manage stress and improve overall emotional health.

Also read: The Power of Spearmint Tea: 7 Health Benefits Of Drinking It On An Empty Stomach 3. Improves Digestion and Metabolism

In addition to its mental benefits, Shankhpushpi tea is known to have a positive impact on digestion. It aids in reducing acidity, constipation, and bloating by promoting the secretion of digestive enzymes and balancing gut flora. Research from the Asian Journal of Pharmaceutical and Clinical Research highlights Shankhpushpi’s role in enhancing digestion, mainly due to its mild laxative effect and capacity to regulate digestive processes. This tea can be particularly helpful when consumed after meals to aid in breaking down food and promoting a smooth digestive process, thus improving metabolism over time. 4. Promotes Heart Health

Shankhpushpi tea also contributes to cardiovascular health. The herb contains antioxidants that reduce oxidative stress, a significant risk factor for heart diseases. A study in the International Journal of Physiology, Pathophysiology, and Pharmacology suggests that Shankhpushpi’s antioxidants can help reduce levels of LDL (bad cholesterol) and prevent arterial plaque build-up, which is crucial for maintaining healthy blood pressure and promoting good cardiovascular health. This tea is beneficial for those looking to incorporate a heart-friendly herb into their diet. 5. Supports Skin Health

Shankhpushpi’s benefits extend to skin health as well, thanks to its anti-inflammatory and antioxidant properties. These properties help combat free radicals that contribute to aging and skin issues such as acne and dullness. When consumed as tea, Shankhpushpi can aid in detoxifying the body, which reflects in clearer, more radiant skin. According to a study in the Journal of Ayurveda and Integrative Medicine, Shankhpushpi’s bioactive compounds can improve skin elasticity and hydration, making it a valuable addition for anyone looking to maintain a youthful appearance naturally.

Also read: Pomegranate Peel Tea: A Natural Remedy for Cough Relief 6. Boosts Immunity

Rich in alkaloids, flavonoids, and other antioxidants, Shankhpushpi tea serves as an immune-boosting drink. These components work to protect cells from oxidative damage and strengthen the body’s natural defense mechanisms. Studies have shown that Shankhpushpi may increase the production of white blood cells and support immune response against common pathogens. With the changing seasons, sipping on Shankhpushpi tea can help in building resilience against seasonal infections and illnesses, making it an ideal choice for immunity enhancement. How to Prepare Shankhpushpi Tea

To make Shankhpushpi tea, you can use dried Shankhpushpi leaves, available at most health stores or online. Here’s a simple recipe:

Ingredients: 1 teaspoon of dried Shankhpushpi leaves

1 cup of water

Honey or lemon for taste (optional)

Instructions: Boil water and add Shankhpushpi leaves.

Let it simmer for 5–10 minutes.

Strain the tea and add honey or lemon if desired.

Enjoy your cup of Shankhpushpi tea 1-2 times daily, preferably in the morning or evening, for maximum benefits. Conclusion

Shankhpushpi tea is a powerful herbal addition to any wellness routine, with a myriad of benefits from cognitive support to improved immunity and digestive health. It offers a holistic approach to well-being, blending ancient wisdom with modern scientific validation. Adding Shankhpushpi tea to your diet can be a valuable step in fostering a balanced and healthy lifestyle. However, as with any herbal supplement, it’s advisable to consult a healthcare provider, especially if you’re pregnant, nursing, or on medication, to ensure it’s suitable for you.

Read more at www.onlymyhealth.com

Key points

LLMs don’t enhance but “optimize” thinking by structuring ideas, synthesizing data, and fostering creativity.

Free from the limitations of chemical enhancers, LLMs improve problem-solving and foster creativity.

Over-reliance and biases are risks; thoughtful integration and critical use are important.

Art: DALL-E/OpenAI Source: Art: DALL-E/OpenAI

For centuries, humans have sought ways to sharpen their mental edge, turning to stimulants like caffeine, nootropics , and, more recently, off-label use of prescription medications such as Adderall to enhance focus and memory temporarily. But large language models offer a new process —one that doesn’t directly alter brain chemistry but instead transforms how we engage with our cognitive capabilities. Unlike conventional stimulants or enhancers, LLMs amplify and optimize thinking by structuring thought, synthesizing information, and fostering creativity.

This distinction is critical: LLMs do not enhance cognition in the traditional sense, but they act as powerful amplifiers and scaffolding tools that extend what we can think and achieve. LLMs as Cognitive Optimizers

LLMs work externally to augment cognitive processes, acting as dynamic scaffolding that enhances how we think. They don’t alter the underlying mechanics of cognition but instead optimize how we use our existing abilities. Their adaptability allows them to tailor responses to specific needs, enabling users to tackle complex problems with greater efficiency and depth. Structuring Thought : LLMs organize ideas into coherent frameworks, making it easier to address complex challenges systematically.

Synthesizing Knowledge : They distill vast amounts of information into concise, actionable insights that align with user needs.

Providing Feedback : Acting as cognitive mirrors , LLMs highlight inconsistencies, uncover gaps, and refine reasoning through iterative dialogue.

Encouraging Neuroplasticity : By engaging in problem-solving, creativity, and learning with LLMs, users may stimulate neural pathways, promoting adaptability and cognitive flexibility.

By combining these capabilities, LLMs help users bridge the gap between information overload and meaningful understanding. In this way, they function not just as tools but as collaborative partners in thought, amplifying our capacity for critical and creative thinking . Cognitive Fitness for the Aging Brain

One intriguing application of LLMs is their potential to support cognitive fitness LLMs are their potential to support cognitive fitness , particularly for aging individuals. Research consistently shows that engaging in mentally stimulating activities—like puzzles, learning new skills, or participating in deep conversations—helps maintain cognitive function and may even delay age-related decline. LLMs provide a dynamic, accessible form of this mental exercise.

By interacting with LLMs, older users can engage in iterative problem-solving, explore topics of personal interest, or brainstorm creative projects. These interactions mimic the benefits of real-life discussions and intellectual exploration while offering adaptability and scalability that traditional methods often lack. LLMs provide customizable cognitive workouts tailored to individual preferences, promoting lifelong mental engagement and neuroplasticity. Creativity and Problem-Solving: Amplified

Creativity and problem-solving are hallmarks of peak cognition, and LLMs can amplify both. Through their conversational nature, they serve as collaborative partners, helping users refine and expand ideas. When faced with a complex problem, an LLM can break it down into smaller components, offering structured pathways to resolution while suggesting alternative approaches. For creative pursuits, LLMs inspire divergent thinking by reframing concepts or generating entirely new perspectives.

This iterative dialogue creates a feedback loop that mirrors the benefits of brainstorming with a human partner. However, unlike human collaborators, LLMs are infinitely patient, always available, and capable of drawing from an extensive repository of knowledge. They don’t just enhance creativity; they make it more accessible and sustainable. The Joy of Learning

One of the more surprising advantages of LLMs is the intrinsic joy they bring to the process of learning. Interactions with LLMs tap into the natural human pleasure of curiosity and discovery. Unlike chemically mediated tools, which may provide fleeting bursts of focus or energy, LLMs foster sustained engagement through meaningful dialogue and exploration.

This joy arises from the conversational dynamics of interacting with an LLM. Users can pose questions, test hypotheses, or challenge assumptions, receiving thoughtful responses tailored to their needs. These interactions mimic the intellectual satisfaction of engaging with a mentor or collaborator. The result is an environment where learning is not just effective but enjoyable, motivating users to delve deeper and explore further. Promises and Risks

While LLMs hold significant promise, their use is not without risks. A study in the International Journal of Educational Technology in Higher Education highlights concerns that over-reliance on generative AI tools can lead to cognitive disengagement, procrastination , and diminished memory retention, particularly among students. These findings underscore the importance of using LLMs as supplements to critical thinking rather than replacements for it.

Additionally, widespread reliance on LLMs raises concerns about bias , accuracy, and accessibility. The outputs of LLMs are only as reliable as the data they’re trained on, necessitating critical evaluation by users. Furthermore, disparities in access to technology and digital literacy could widen existing inequalities, limiting the democratizing potential of these tools. Addressing these challenges requires fostering digital literacy, encouraging critical engagement, and integrating LLMs thoughtfully into workflows. The Cognitive Frontier

LLMs represent more than just another step in humanity’s quest for cognitive enhancement—they mark a fundamental shift in how we extend our mental capabilities. Unlike traditional tools that alter our brain chemistry, LLMs serve as intellectual mirrors and catalysts, amplifying our natural cognitive abilities through structured dialogue and collaborative exploration.

What makes them revolutionary is their unique combination of human-like interaction with machine-like capabilities, creating something unprecedented: a tool that doesn’t just enhance our thinking, but transforms how we understand and develop our own cognitive capabilities. The key lies not in LLMs replacing human thought but in their ability, but in their ability to help us think better, learn deeper, and explore further than ever before—potentially redefining the very boundaries of human cognitive potential.

Read more at www.psychologytoday.com

Research shows a little mental replay will help you remember more, and for a long longer. Illustration: Getty Images. Knowledge is power, as long as you actually put that knowledge to use. Success in any pursuit is based on what you do with what you know: It follows that the more you retain and remember, the more you can do.

There are plenty of simple ways to improve your memory. Interleaving, learning, or practicing more than one subject or task in succession . Distributed practice, intentionally spacing out learning sessions . Literally sleeping on it . Even chewing gum .

But my favorite involves memory consolidation, the process of transforming temporary memories into more stable, long-lasting memories. Even though the process of memory consolidation can be sped up , still: storing a memory in a lasting way takes time. The 40-second replay

One way to increase the odds is to replay whatever you want to remember for about 40 seconds. A study published in Journal of Neuroscience found that a brief period of rehearsal — like replaying an event in your mind, replaying what someone said, or replaying a series of steps you want to take — makes it much more likely you will remember what you replayed.

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For example, I’ve never forgotten the time Mark Cuban told me , “No one’s time is so valuable they can’t be nice.” Partly that’s because the situation itself was memorable , but that’s also because I re-lived that moment as he walked away, and thought about it later in the day as well.

As the researchers write: Memories are strengthened via consolidation. We investigated memory for lifelike events using video clips and showed that rehearsing their content dramatically boosts memory consolidation. Using MRI scanning, we measured patterns of brain activity while watching the videos and showed that, in a network of brain regions, similar patterns of brain activity are reinstated when rehearsing the same videos. Within the posterior cingulate, the strength of reinstatement predicted how well the videos were remembered a week later. The findings extend our knowledge of the brain regions important for creating long-lasting memories for complex, lifelike events. Or in non-researcher speak, replaying an event has a major effect on your ability to remember complex, lifelike events, in part because those memories get stored across a range of brain regions, and because replaying the event adds context. How to remember names

Say, like me, you’re terrible at remembering people’s names. When you walk away after being introduced, take 30 or 40 seconds to replay the introduction. What you said. What they said. How they looked, how you felt, what was happening around you – play the “video” in your mind.

Do that, and you’ll be much more likely to remember that person’s name, as well as other things they, and you, said.

The 40-second technique also works for things you’ve been shown how to do. An electrician showed me how to wire a three-way circuit. Thirty minutes later, when i tried to do it myself, I couldn’t.

I went back and asked him to show me again – but this time, when he was done, I took a few minutes to replay his demonstration. I tried to remember what he said, what he did, what I was thinking. It worked.

Later, I still had to ask him one question, but I basically had gotten it. Failing one part of the “test” also helped me remember how to do it. Research shows testing yourself, whether formally or inadvertently, dramatically improves retention .

Memory consolidation works, especially if you make it an intentional, active process. So start replaying. You’ll remember more – and be able to do more with what you know.

Read more at www.inc.com

Hard-charging entrepreneurs used to brag about how little sleep they got. Thankfully, we’ve moved past that.

NOV 29, 2024 Illustration: Getty Images It happens to all of us, and yet most of us have been told there’s nothing we can do about it.

You have a bad night’s sleep. Maybe you were out having fun, maybe you were up doing work. Maybe you tossed and turned and tried, but you just couldn’t switch off your brain.

Then, it’s morning, and you’re exhausted.

You can’t wait for the day to be done, because you just want to get to bed. Or else maybe you motor on, caffeinated but cranky, convinced that even if you found the time for a short nap it wouldn’t do much for you, because REM sleep is supposedly the only sleep that really matters.

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Fret not, my sleep-deprived friend, because new neuroscience suggests that NREM sleep—meaning, straightforwardly, “non-rapid eye movement” phases of sleep—has specific benefits for the performance of the neurons in your brain.

Researchers at Rice University, Houston Methodist’s Center for Neural Systems Restoration, and Weill Cornell Medical College say they’ve uncovered some key secrets that might, in the words of an official summary , “chang[e] our fundamental understanding of how sleep boosts brainpower.”

Specifically, the summary continues, their research “reveals how NREM sleep—the lighter sleep one experiences when taking a nap, for example—fosters brain synchronization and enhances information encoding, shedding new light on this sleep stage.”

Their study was interesting, and frankly sounds kind of adorable. Using macaques as test subjects, which are a type of monkey, the researchers had the animals “perfor[m] a visual discrimination task” both before and after they were allowed 30 minutes of NREM sleep. Napping secrets

Put in layperson’s terms: They had the primates take a test, then let them take a 30-minute nap, and then had them take a similar test again.

The results, as you might imagine since they wrote an entire research paper about it, published in the most recent edition of the journal Science , were that the macaques performed better on the test after having had the pleasure of a nap.

“During sleep, we observed an increase in low-frequency delta wave activity and synchronized firing among neurons across different cortical regions,” said study author Natasha Kharas, who is a resident in neurological surgery at Weill Cornell. “After sleep, however, neuronal activity became more de-synchronized compared to before sleep, allowing neurons to fire more independently. This shift led to improved accuracy in information processing and performance in the visual tasks.”

Apparently, as a control, they also had macaques who were allowed to rest but not fall asleep do the tasks for a second time, but did not see the improved performance.

Afterward, the researchers attempted to determine if they could stimulate the same kinds of effects in the brain that are derived from NREM sleep without the animals actually having to nap, by using “low-frequency electrical stimulation of the visual cortex.” Surprising benefits

While less adorable than the idea of a bunch of monkeys having nap time together in a lab, the researchers said this artificial NREM sleep nevertheless resulted in similar improved performance.

While that wouldn’t impart other benefits of sleep besides these types of brain functions, it does suggest the possibility of a whole world of other practical applications.

Imagine, for example, finding ways to boost brainpower among people with sleep disorders, or even those who for practical reasons might not be able to get as much sleep as they need; think rescue personnel, soldiers, or as the study authors suggested, astronauts in space.

“Our study not only deepens our mechanistic understanding of sleep’s role in cognitive function but also breaks new ground by showing that specific patterns of brain stimulation could substitute for some benefits of sleep, pointing toward a future where we might boost brain function independently of sleep itself,” said study co-author Valentin Dragoi, a professor of neuroscience at Weill Cornell.

I’ve been writing about these kinds of subjects long enough to remember when hard-charging entrepreneurs would brag about how little sleep they got each night. Thankfully, we’ve moved past that.

We all have those days when we just didn’t get enough shuteye. Now, maybe you’ve got a bit more evidence to suggest it might be worth working a 30-minute or so catch-up into your day when that happens.

Find a cozy spot, doze off, and maybe dream of napping macaques.

The opinions expressed here by Inc.com columnists are their own, not those of Inc.com.

Read more at www.inc.com

Cheap Daily Supplement Seems to Boost Brain Function in Older Adults What’s good for your aging gut may also be good for your aging brain. The first study of its kind in twins has found that taking daily protein and prebiotic supplements can improve scores on memory tests in people over the age of 60.

The findings are food for thought, especially as the same visual memory and learning test is used to detect early signs of Alzheimer’s disease.

The double-blinded trial involved two cheap plant fiber prebiotics that are available over the counter in numerous nations around the world. Prebiotics are non-digestible consumables that help stimulate our gut microbes.

One is called inulin , and it is a dietary fiber in the class fructan. Another is called fructooligosaccharide (FOS), and it is a plant carbohydrate often used as a natural low calorie sweetener. Fructooligosaccharide is often used as a natural low calorie sweetener. ( towfiqu barbhuiya/Canva ) To test the effect of these supplements on the aging brain, researchers at King’s College London enrolled 36 pairs of twins over the age of 60.

Each duo was randomly split so that one twin was assigned a daily prebiotic in a protein powder and the other was assigned a daily placebo in a protein powder.

The twin who unknowingly took inulin or FOS generally scored higher on a cognitive test three months later.

What’s more, the daily fiber supplements were linked to slight changes in the gut microbiome between twins. The beneficial Bifidobacterium , for instance, were more plentiful in twins taking inulin or FOS.

Studies on mice suggest Bifidobacterium reduces cognitive deficits by regulating gut-brain connections. Daily fiber supplements were linked to slight changes in the gut microbiome between twins. ( troyanphotos/Canva ) “We are excited to see these changes in just 12 weeks. This holds huge promise for enhancing brain health and memory in our aging population,” said Mary Ni Lochlainn, a geriatric medicine researcher at King’s College London, when the findings were published in March.

“Unlocking the secrets of the gut-brain axis could offer new approaches for living more healthily for longer.”

King’s College is home to the United Kingdom’s largest adult twin registry, and twin studies are highly valuable when it comes to differentiating between the effect of genetics and the environment on human health.

Past studies on rodents suggest that high-fiber supplements, like inulin and FOS, can ‘feed’ the colon’s microbiome, allowing ‘good’ bacteria to thrive.

Some of these bacterial players are also linked to improved cognitive function in both mice and humans . Twin studies are highly valuable when it comes to differentiating between the effect of genetics and the environment on human health. ( recep-bg/Canva ) Evidence for the close relationship between the gut and the brain is growing year after year . Some experts are now so convinced by the results, they refer to the gut as the body’s ‘second brain’.

But the way these two nervous systems work together remains a mystery.

The recent twin study at KCL suggests that consuming certain ‘brain foods’ may be a promising way to treat cognitive decline.

But while prebiotics might improve some aspects of cognitive function in an aging brain, like memory and processing times, there don’t appear to be significant physical benefits.

Muscle loss didn’t improve among aging twins taking high-fiber supplements, despite the fact that inulin and FOS are important factors in musculoskeletal maintenance.

“These plant fibers, which are cheap and available over the counter, could benefit a wide group of people in these cash-strapped times. They are safe and acceptable too,” said geriatrician Claire Steves at KCL.

“Our next task is to see whether these effects are sustained over longer periods and in larger groups of people.” What’s good for your aging gut may also be good for your aging brain. ( Robert Kneschke/Canva ) The twins that participated in the current trial were mostly female, and even though the researchers adjusted for sex differences in their findings, they acknowledge that there may be some selection bias amongst KCL’s twin cohort.

That said, females are more susceptible to Alzheimer’s disease, and studies like the current one support the emerging idea that cognitive decline is not always a disease of the brain , but may involve external factors, too.

The gut has its fingers in many bodily ‘pies’, including the immune system and the central nervous system. Feeding its microbiome certain prebiotics and probiotics could open the door to treating a plethora of illnesses and diseases.

The study was published in Nature Communications .

An earlier version of this article was published in March 2024. Related News

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Read more at news.yahoo.com