There are so many misconceptions out there about the MK-677 compound that it’s only fair that we start this article by debunking some myths. First of all, MK-677 is also known as Ibutamoren, Nutrobal or Ibutamoren Mesylate depending on who you’re talking to.
In fact, there are several clinical studies whose data indicates that Ibutamoren can effectively boost GH levels.
If you visit popular online fitness forums, you’re likely to come across a few discussions about Ibutamoren. Many bodybuilders swear by its ability to increase growth hormone levels, and it’s easy to purchase since it’s available over-the-counter.
How does it work? Well, the data tells us that MK-677 simulates the action of the ghrelin hormone which makes it possible for it to bind with ghrelin receptors (GHSR) in the brain. Once activated, GHSR triggers a natural hormone release.
Part of what makes Ibutamoren so popular is the fact that it doesn’t affect other hormones like cortisol and mostly works to increase GH levels exclusively.
Of course, let’s not forget Ibutamoren’s ability to increase GH levels in the body without affecting other hormones like cortisol. You see, most other GH-boosting compounds tend to increase cortisol levels as well, which leads to a weak immune system. MK-677 doesn’t come with that side effect and yet it’s just as potent and effective at increasing GH levels.
A well-known benefit of MK-677 is its ability to increase lean body mass. As such, it can be a very effective anabolic. Most people recommend taking it orally twice per day at the recommended dose to experience similar benefits to what you’d get with growth hormone stimulators.
Due to its ability to increase IGF-1 and GH levels, Ibutamoren is a great way to create bigger muscles, reduce body mass and improve overall strength.
In fact, a double-blind randomized controlled trial with 24 obese male subjects revealed that MK-677 has the ability to increase lean muscle mass. Not only that but the subjects experienced an increase in basal metabolic rate (BMR) over a period of just two months.
Muscle wasting is always a concern among bodybuilders, which is why many turn to MK-677 to avoid this fate. Another double-blind randomized controlled trial done with 8 food-deprived volunteers indicates that Ibutamoren can actually reverse protein loss and muscle wasting.
Yet another randomized controlled trial with 123 elderly patients showed that MK-677 can improve muscle strength in aging individuals.
It’s a well-known fact that growth hormone (GH) has the ability to increase bone density and turnover. But the weird thing is that bone density will start by decreasing before it increases, and it can take up to 1 year to see the desired results in bone density.
A study done with 24 obese males showed that MK-677 can increase bone turnover. Meanwhile, a study involving 187 elderly adults showed that MK-677 can boost bone building in old age according to a bone turnover marker known as Osteocalcin.
Another study conducted on 292 post-menopausal women showed that Ibutamoren can also increase bone mineral density and this leads to osteoporosis prevention and boosted bone strength.
According to a double-blind randomized controlled trial on young and elderly subjects, MK-677 has the ability to improve sleep quality and duration. This is good news for any athlete that needs fast recovery from hectic training.
This is further confirmed by anecdotal accounts on online forums where many users list improved sleep quality as one of the benefits they’ve experienced when taking Ibutamoren. All in all, MK-677 is a great way to biohack insomnia and improve the quality of your sleep so that you can deliver your best performance during the day.
As we age, so does the level of muscle mass and Growth Hormone Secretion decrease. This decline usually begins in mid-puberty and continues on until we die.
To demonstrate, a double-blind randomized controlled trial with 65 elderly adults (male and female) showed that a daily intake of Ibutamoren can restore IGF-1 and GH levels to a healthy level. Plus, no side-effects were observed during the trial.
In a similar study involving 24 obese males, MK-677 was shown to significantly improve the subjects’ growth hormone profile.
Another interesting effect of MK-677 is that it can act as a nootropic in some cases. This is all thanks to its ability to act as a ghrelin receptor. But there isn’t enough scientific research on the effects of Ibutamoren on cognitive performance to call it a proper nootropic just yet.
But Ibutamoren may improve cognitive function through these two indirect mechanisms:
It’s worth noting that Ibutamoren has the ability to increase IGF-1 and IGFBP-3 levels which are essential for children suffering from growth hormone deficiency. The best part is that these benefits can be achieved without affecting insulin, cortisol, thyrotropin, thyroxine (T4), triiodothyronine (T3), glucose and prolactin.
In another study involving extremely GH-deficient male subjects, MK-677 was able to effectively increase their growth hormone and IGF-1 levels without affecting their thyroid, PRL or cortisol hormone levels.
But Ibutamoren was shown to increase glucose and insulin levels in these subjects.
Although Ibutamoren doesn’t come with any adverse side effects, users have been shown to experience the odd muscle pain, mild lower extremity edema, and increased appetite.
It’s recommended to always watch carb intake while cycling with Ibutamoren in order to keep insulin and blood sugar levels balanced. Cancer patients must also stay away from Ibutamoren because as an anabolic, it can actually help cancer cell growth. MK-677 is also not recommended for TH1 dominant individuals.
Ibutamoren has a half-life of 24 hours which means it is best taken once per day. But even a single dose of this compound can instantly increase GH levels. Tiredness and lethargy usually follow this effect, which is why it’s recommended to take Ibutamoren in two doses per day.
When purchasing Ibutamoren, be sure to mention that you want it as a research chemical, or else no reputable vendor will sell it to you. Speaking of which, we highly recommend you buy MK-677 from a reliable supplier like Boss Peptides. These guys are trusted for their ability to consistently provide a quality product, and they’re always willing to provide you with third-party lab tests as proof of the compound’s authenticity and quality.