Stanford researchers enhance neuron recovery in rats after blood flow stalls

Researchers at the Stanford University School of Medicine report in a new study that they found a way to help rats recover neurons in the brain’s center of learning and memory. They accomplished the feat by blocking a molecule that controls how efficiently genetic instructions are used to build proteins. If the approach described in the study can be applied to humans, it may one day help patients who’ve suffered a stroke, cardiac arrest or major blood loss and are thus at higher risk of memory loss. In the study, to be published online Aug. 19 in eNeuro , researchers induced extremely low blood pressure — as would happen when the heart stops beating — in rats. These rats lost neurons in a specific region of the hippocampus critical to learning and memory, but the researchers improved the animals’ recovery of the cells by injecting a molecule that blocks a microRNA: a short molecule that tweaks gene activation by preventing the conversion of genetic blueprints into proteins. Interestingly, the scientists found that a microRNA blockade potentially causes astrocytes — cells that support neurons and make up 50% of the cells in the brain — to turn into neurons. The findings demonstrate that neurons, with some assistance from their astrocyte neighbors, recover in a region of the hippocampus not known to have a local stem cell population that can replenish lost neurons. Enhancing this recovery in humans could help those who’ve suffered a temporary loss of blood flow to the brain. "There’s currently no treatment to improve brain function in patients with heavy blood loss, cardiac arrest or stroke," said Creed Stary, MD, PhD, assistant professor of anesthesiology, perioperative and pain medicine. "This is the first study to show that the natural process of post-injury hippocampal recovery can be substantially […]

Click here to view full article