Magnesium l-threonate is a synthesized form of magnesium that can boost cognitive abilities. Learn how it’s used to improve memory and reverse brain aging.
Magnesium is so important for health that it’s been called the master mineral .
It’s particularly important for a healthy brain and nervous system.
It exhibits anti-stress, anti-anxiety, anti-depressive, and neuroprotective properties.
But there’s always been a quandary with the therapeutic use of magnesium supplements for cognitive and mental health issues — they do not readily cross into the brain.
Now there’s a new breakthrough form of magnesium, magnesium l-threonate, that solves this problem. What Is Magnesium L-Threonate?
Most magnesium supplements are chelated and magnesium l-threonate is no exception.
Chelated simply means that the magnesium molecules are bonded to another molecule.
Chelation can improve a magnesium supplement’s stability, absorption, and bioavailability. ( 1 )
Magnesium l-threonate is the latest magnesium chelate.
It was developed by a team of neuroscientists at Massachusetts Institute of Technology and Tsinghua University in Beijing who bound magnesium to l-threonate , a vitamin C metabolite. ( 2 )
There is no reason to be concerned that magnesium l-threonate is not natural.
When it comes to magnesium supplements, natural is not necessarily better.
Magnesium sulfate naturally occurs in Epsom salts, but it’s a harsh laxative that’s barely absorbed.
This makes it one of the worst forms of magnesium that you can take, especially if improving brain function is your goal. ( 3 )
You may already be familiar with popular magnesium supplements like magnesium citrate and magnesium glycinate.
They, too, are synthesized in a laboratory. How Does Magnesium L-Threonate Work?
Magnesium is largely missing from the modern diet.
Magnesium is the second most common deficiency in industrialized countries. ( 4 )
Here in the US, only 32% of us get the RDA (recommended daily allowance) of magnesium. ( 5 )
The brain’s need for magnesium is high — it is found in higher concentrations in the brain than in the blood.
Magnesium plays a critical role in a number of brain-related and neurological conditions including: ( 6 , 7 , 8 , 9 , 10 ) acute brain injury
attention disorders bipolar disorder dementia depression Parkinson’s disease schizophrenia seizures But frustratingly, very little of the magnesium found in typical supplements gets into the brain, limiting its therapeutic value. The blood-brain barrier. Magnesium l-threonate was specifically created to cross the brain’s protective filter, the blood-brain barrier. ( 11 )Another brain-enhancing property of magnesium l-threonate is that it increases brain plasticity . ( 12 )Neuroplasticity is the brain’s ability to change and grow, and is fundamental for memory and learning to take place.Lastly, there’s evidence that magnesium l-threonate can increase brain-derived neurotrophic factor (BDNF), a protein that stimulates the formation of new brain cells. WHAT CAN A BRAIN SUPPLEMENT DO?Are you struggling with …➤ Fuzzy thinking and foggy focus?➤ Growing forgetfulness?➤ Shrinking ability to learn and problem-solve?➤ Lack of mental energy and drive?Mind Lab Pro can help your brain perform better. Dr. Pat | Be Brain Fit Benefits of Magnesium L-Threonate: What the Research Shows There are dozens of known magnesium benefits.Appropriate magnesium supplementation has been proven to lift mood, increase resilience to stress, improve focus and concentration, raise energy levels, and improve sleep quality. ( 13 )It’s also good for a wide variety of conditions not related to brain health such as asthma, muscle cramps, high blood pressure, osteoporosis, and heart disease.Magnesium l-threonate has been around only since 2010.So unlike many other natural supplements, it has no history of traditional or medicinal use.This makes research results more important than usual.Of the dozen or so studies done on magnesium l-threonate, there’s been only one clinical trial (i.e., study on humans).Since this study is by far the most relevant, let’s take a look at this one first. Magnesium L-Threonate Clinical Trial Results There’s only one clinical trial that’s been published in a peer-reviewed medical journal.Study participants were older adults (ages 50 through 70) who reported concerns with memory, concentration, anxiety, and sleep. ( 14 )They were evaluated for four aspects of cognitive ability — working memory, episodic memory, attention, and executive function — the last being a group of skills that helps you set goals, plan, and get things done.They were given magnesium l-threonate for 12 weeks.As researchers expected from the results of animal tests, magnesium l-threonate increased magnesium levels in human brain cells.When retested, all participants performed significantly better in all four cognitive areas.Magnesium l-threonate also significantly reduced their biological brain age.On average, these seniors’ brains functioned as if they were 9.4 years younger than when the study began, according to standard tests.For most participants, this effectively reversed their brain age back to their chronological age.This is very encouraging news!However, magnesium l-threonate did not help with sleep, mood, or anxiety any better than a placebo.(This study used ClariMem, a trademarked form of magnesium l-threonate. It is also called MMFS-01. At this time, according to the product website, ClariMem is currently out of stock.) Magnesium L-Threonate Animal Study Results This compound is still new and more human tests will certainly be forthcoming.Until then, here’s what animal research has discovered so far. Magnesium L-Threonate and Anxiety Disorders Magnesium l-threonate may be helpful for anxiety disorders.Magnesium is highly regarded as a natural relaxant.It works by increasing the calming neurotransmitter GABA, while reducing the release of stress hormones. ( 15 )It also works at the blood-brain barrier to prevent stress chemicals from entering the brain. ( 16 )The results of animal research suggest that magnesium l-threonate could be particularly helpful for anxiety disorders, such as phobias and post-traumatic stress disorder, but human studies are needed. ( 17 ) ARE YOU FEELING UNFOCUSED?Scientifically personalized music can boost focus 4X.Whatever work or study you do, Focus@Will can help you do it better and faster:➤ Works with your type of brainwave patterns to reduce distractions.➤ Dramatically improves your concentration, learning, and retention.➤ Adapts dynamically to fit your needs and keep you in a “flow state.” Dr. Pat | Be Brain Fit Magnesium L-Threonate and Dementia and Alzheimer’s Magnesium l-threonate shows potential for treating […]